Liposomes Encapsulating Artocarpus lakoocha Roxb. and Glycyrrhiza glabra L. Extracts: Characterization and Shelf Life of Freeze-Dried Vesicles

Simple item page
dc.contributor.authorTasanee Panichakul
dc.contributor.authorPiyawan Youdee
dc.contributor.authorNattaporn Boohuad
dc.contributor.authorKhwunjit Itsarasook
dc.contributor.authorPrasit Suwannalert
dc.contributor.correspondenceT. Panichakul; Department of Cosmetic Science, Faculty of Science and Technology, Suan Dusit University, Bangkok, 10300, Thailand; email: tasanee_p@yahoo.com
dc.date.accessioned2025-03-10T07:36:05Z
dc.date.available2025-03-10T07:36:05Z
dc.date.issued2020
dc.description.abstractLiposome is the one way of encapsulation of extracts for reducing the extract degradation. This study was to prepare the liposome entrapped extracts of Artocarpus lakoocha Roxb. (L-Al), Glycyrrhiza glabra L. (L-Gg) alone and in combination of A. lakoocha and G. glabra extracts (L-AlGg). The liposomes were prepared by Mechanochemical method and freeze-drying. For stability of liposomes, storage at 4, 25 and 45¡C for 8 weeks was performed. The trapping efficiency of liposomes and tyrosinase inhibitory activities of extracts entrapped in liposome were investigated. Results showed liposome morphology was the spherical vesicles evaluated by TEM. Before freeze-drying, liposomes had particle sizes of 156.966 ± 0.808, 140.8 ± 0.818 and 158.633 ± 4.193 nm for L-Al, L-Gg and L-AlGg, respectively. The entrapment efficiency of L-Al, L-Gg and L-AlGg was found to be 95.83 ± 13.48, 97.99 ± 5.23 and 93.90 ± 16.28 %, respectively. The tyrosinase inhibitory activities of released extracts from L-Al, L-Gg and L-AlGg were 81.57 ± 1.22, 68.92 ± 1.23 and 81.40 ± 0.64 %, respectively. After freeze-drying, the particle sizes of L-Al and L-AlGg were no significant changes, while L-Gg particle size was bigger (p < 0.01). The liposome entrapment and tyrosinase inhibitory activity of released extracts were not significantly changed after freeze-drying. This indicates good stability and no extract leakage of liposomes. In storage at 4¡C for 8 weeks, the entrapment efficiency of L-Al, L-Gg, L-AlGg and tyrosinase inhibitory activity of released extracts were not significantly different, comparing with controls. When increasing temperature of storage effected on the significantly reduction of the entrapment of liposomes and the tyrosinase inhibitory activity of released extracts (p < 0.01). Therefore, the freeze-dried liposome and storage at low temperature is recommended for stabilizing liposome and extract quality. © 2020, Research and Development Institute Suan Dusit University. All rights reserved.
dc.identifier.citationJournal of Food Health and Bioenvironmental Science
dc.identifier.issn26300311
dc.identifier.scopus2-s2.0-85207303521
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/4746
dc.languageEnglish
dc.publisherResearch and Development Institute Suan Dusit University
dc.rights.holderScopus
dc.subjectArtocarpus lakoocha Roxb
dc.subjectGlycyrrhiza glabra L.
dc.subjectLiposome
dc.subjectStability
dc.titleLiposomes Encapsulating Artocarpus lakoocha Roxb. and Glycyrrhiza glabra L. Extracts: Characterization and Shelf Life of Freeze-Dried Vesicles
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85207303521&partnerID=40&md5=14bcf3c26d981356d329abed6b581023
oaire.citation.endPage9
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.volume13
Files
Collections
SCOPUS 2020