Small rna interference inhibition of ubiquitin-specific protease 14 gene expression in intrahepatic cholangiocarcinoma primary cells
| dc.contributor.author | Ubol Chuensumran | |
| dc.contributor.author | Tasanee Panichakul | |
| dc.contributor.author | Thun Ingkakul | |
| dc.contributor.author | Poom Adisakwattana | |
| dc.contributor.correspondence | U. Chuensumran; Department of Food Processing Technology, School of Culinary Arts, Suan Dusit University, Bangkok, 10300, Thailand; email: ubol_chu@dusit.ac.th | |
| dc.date.accessioned | 2025-03-10T07:36:05Z | |
| dc.date.available | 2025-03-10T07:36:05Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Studies on genomic instabilities of intrahepatic cholangiocarcinoma (ICC) from Thai patients have shown 52% variations in a specific region of ubiquitin-specific protease 14 gene (USP14) located on 18p11.32. Inhibition of USP14 expression in three different primary cells cultured from resected ICC tissues by transfecting with double-strand RNA interference targeting exon 16 region of USP14 mRNA resulted in 6-50% reduction in mRNA levels, with cells with low USP14 expression being more affected. These findings lend support to a potential in developing strategies against USP14 in ICC. © 2020, SEAMEO TROPMED Network. All rights reserved. | |
| dc.identifier.citation | Southeast Asian Journal of Tropical Medicine and Public Health | |
| dc.identifier.issn | 1251562 | |
| dc.identifier.scopus | 2-s2.0-85114373400 | |
| dc.identifier.uri | https://repository.dusit.ac.th//handle/123456789/4760 | |
| dc.language | English | |
| dc.publisher | SEAMEO TROPMED Network | |
| dc.rights.holder | Scopus | |
| dc.subject | Intrahepatic cholangiocarcinoma | |
| dc.subject | Primary cell culture | |
| dc.subject | RNAi | |
| dc.subject | Ubiquitin-specific protease 14 | |
| dc.title | Small rna interference inhibition of ubiquitin-specific protease 14 gene expression in intrahepatic cholangiocarcinoma primary cells | |
| dc.type | Article | |
| mods.location.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114373400&partnerID=40&md5=38fdc80a7400c0aedd363234ccb5b1de | |
| oaire.citation.endPage | 700 | |
| oaire.citation.issue | 5 | |
| oaire.citation.startPage | 696 | |
| oaire.citation.volume | 51 |