Ethanol extract of Terminalia chebula fruit protects against UVB-induced skin damage

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dc.contributor.authorSwanya Yakaew
dc.contributor.authorKhwunjit Itsarasook
dc.contributor.authorJatuporn Ngoenkam
dc.contributor.authorArum Jessadayannamaetha
dc.contributor.authorJarupa Viyoch
dc.contributor.authorMalyn Ungsurungsie
dc.contributor.correspondenceM. Ungsurungsie; Research & Development Division, S & J International Enterprises Public Company Limited, Bangkok, Thailand; email: malynthai@gmail.com
dc.date.accessioned2025-03-10T07:36:30Z
dc.date.available2025-03-10T07:36:30Z
dc.date.issued2016
dc.description.abstractContext: The fruit of Terminalia chebula Retz. (Combretaceae) has been used for several therapeutic purposes in Thai folk medicines. Currently, the ethanol extracts containing antioxidant compounds have shown the ability to promote collagen synthesis. Objective: This purpose of this work was to study the effects of the ethanol extract from T. chebula fruit on the inhibition of cutaneous photodamage. Materials and methods: The viability of human skin fibroblasts after incubation with T. chebula at concentration 0.5�50 _g/mL for 24, 48 and 72 h was assessed by using sodium 3_-[(phenyl-amino)-carbonyl]-3,4,tetrazolium-bis(4-methoxy-6-notro)benzene-sulphonic acid hydrate (XTT). The levels of type I procollagen and matrix metalloproteinases (MMP)-1 and MMP-13 produced by UVB-irradiated fibroblasts were determined by ELISA. Skin thickness and collagen content caused by long-term UVB irradiation in male ICR mice were determined from haematoxylin and eosin stained tissue sections and spectrophotometric measurement of hydroxyproline. Results: The extract (0.5�50 _g/mL) had no effect on cell viability or morphology of the human fibroblasts. In vitro studies showed that the T. chebula extract reduced the UVB-induced MMP-1 and MMP-13 expression, whereas an increased production of type I procollagen was observed. In a UVB-irradiated animal model, male ICR mice with hair shaved were chronically exposed to UVB which lead to epidermal thickness and loss of hydroxyproline. However, these effects were fully prevented by the topical application of the T. chebula ethanol extract. Discussion and conclusion: These data suggested that the T. chebula ethanol fruit extract is an efficacious pharmaceutical protectant of skin against photodamage. � 2016 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.citationPharmaceutical Biology
dc.identifier.doi10.1080/13880209.2016.1179768
dc.identifier.issn13880209
dc.identifier.scopus2-s2.0-84969851232
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/4823
dc.languageEnglish
dc.publisherTaylor and Francis Ltd
dc.rightsAll Open Access; Bronze Open Access
dc.rights.holderScopus
dc.subjectAntiageing
dc.subjectantioxidant
dc.subjectmatrix metalloproteinases
dc.subjectphotodamaged
dc.subjecttype I procollagen
dc.titleEthanol extract of Terminalia chebula fruit protects against UVB-induced skin damage
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84969851232&doi=10.1080%2f13880209.2016.1179768&partnerID=40&md5=61c8841ea78c26ca4d1693c0a550c8bd
oaire.citation.endPage2707
oaire.citation.issue11
oaire.citation.startPage2701
oaire.citation.volume54
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