Evaluation of Terminalia chebula Retz. Extract Against Caries-associated Bacteria as an Alternative Compound for Oral Care Products

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dc.contributor.authorPiyanuch Prompamorn
dc.contributor.authorKhwunjit Itsarasook
dc.contributor.authorJitrawadee Tanghiranrat
dc.contributor.authorChanchai Tripetch
dc.contributor.authorKanlayaporn Chantree
dc.contributor.correspondenceP. Prompamorn; Faculty of Science and Technology, Suphanburi Campus, Suan Dusit University, Suphanburi, 72000, Thailand; email: Piyanuch_pro@dusit.ac.th
dc.date.accessioned2025-03-10T07:35:06Z
dc.date.available2025-03-10T07:35:06Z
dc.date.issued2022
dc.description.abstractThe objective of this study was to investigate the efficiency of Terminalia chebula Retz. fruit extract for further use as an active ingredient in oral care products. The quantification of major constituent, the antioxidant activity and antibacterial activity of an extract against Streptococcus mutans in both planktonic and biofilm form were measured. The results showed that ellagic acid was the major constituent of an extract and the amount of ellagic acid contained in the extract was 36.671 mg/g. The extract exhibit free radical scavenging activity with IC50 value of 0.44±0.01 mg/mL by DPPH assay. For antibacterial activity against S. mutans, T. chebula Retz. extract possess high inhibitory effect on S. mutans in both planktonic form and biofilm form. The MIC50 and MBC value of an extract against planktonic form of S. mutans were 0.47±0.28 and 6.25 mg/mL, respectively. For biofilm form of S. mutans, the extract has a high capability to preventing biofilm formation and eradicating the existing biofilm. The MBIC50 and MBEC50 of an extract against biofilm form of S. mutants were 4.47±0.32 and 9.64±0.39 mg/mL, respectively. © 2022, Research and Development Institute Suan Dusit University. All rights reserved.
dc.identifier.citationJournal of Food Health and Bioenvironmental Science
dc.identifier.issn26300311
dc.identifier.scopus2-s2.0-85207276755
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/4602
dc.languageEnglish
dc.publisherResearch and Development Institute Suan Dusit University
dc.rights.holderScopus
dc.subjectBiofilm
dc.subjectDental caries
dc.subjectStreptococcus mutans
dc.subjectTerminalia chebula Retz.
dc.titleEvaluation of Terminalia chebula Retz. Extract Against Caries-associated Bacteria as an Alternative Compound for Oral Care Products
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85207276755&partnerID=40&md5=673ca05e223cbe437f61d1b9d5fb1f1a
oaire.citation.endPage50
oaire.citation.issue2
oaire.citation.startPage43
oaire.citation.volume15
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