Meta-analysis and sensitivity analysis for multi-arm trials with selection bias

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dc.contributor.authorHathaikan Chootrakool
dc.contributor.authorJian Qing Shi
dc.contributor.authorRongxian Yue
dc.contributor.correspondenceJ.Q. Shi; School of Mathematics and Statistics, University of Newcastle, Newcastle NE1 7RU, United Kingdom; email: j.q.shi@ncl.ac.uk
dc.date.accessioned2025-03-10T07:37:41Z
dc.date.available2025-03-10T07:37:41Z
dc.date.issued2011
dc.description.abstractMulti-arm trials meta-analysis is a methodology used in combining evidence based on a synthesis of different types of comparisons from all possible similar studies and to draw inferences about the effectiveness of multiple compared-treatments. Studies with statistically significant results are potentially more likely to be submitted and selected than studies with non-significant results; this leads to false-positive results. In meta-analysis, combining only the identified selected studies uncritically may lead to an incorrect, usually over-optimistic conclusion. This problem is known asbiselection bias. In this paper, we first define a random-effect meta-analysis model for multi-arm trials by allowing for heterogeneity among studies. This general model is based on a normal approximation for empirical log-odds ratio. We then address the problem of publication bias by using a sensitivity analysis and by defining a selection model to the available data of a meta-analysis. This method allows for different amounts of selection bias and helps to investigate how sensitive the main interest parameter is when compared with the estimates of the standard model. Throughout the paper, we use binary data from Antiplatelet therapy in maintaining vascular patency of patients to illustrate the methods. © 2011 John Wiley & Sons, Ltd.
dc.identifier.citationStatistics in Medicine
dc.identifier.doi10.1002/sim.4143
dc.identifier.issn10970258
dc.identifier.scopus2-s2.0-79955597648
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/5013
dc.languageEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.rights.holderScopus
dc.subjectHeterogeneity
dc.subjectMeta-analysis
dc.subjectMixed treatment comparisons
dc.subjectMulti-arm trials
dc.subjectSelection bias
dc.subjectSensitivity analysis
dc.titleMeta-analysis and sensitivity analysis for multi-arm trials with selection bias
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79955597648&doi=10.1002%2fsim.4143&partnerID=40&md5=3b5dda1265606b37e60fbf05be5f7d7b
oaire.citation.endPage1198
oaire.citation.issue11
oaire.citation.startPage1183
oaire.citation.volume30
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