Ultrastructural alterations in the liver and kidney of white sea bass, Lates calcarifer, in acute and subchronic cadmium exposure

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dc.contributor.authorSuchada Thophon
dc.contributor.authorPrayad Pokethitiyook
dc.contributor.authorKashane Chalermwat
dc.contributor.authorE. Suchart Upatham
dc.contributor.authorSomphong Sahaphong
dc.contributor.correspondenceP. Pokethitiyook; Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand; email: grpph@mahidol.ac.th
dc.date.accessioned2025-03-10T07:38:30Z
dc.date.available2025-03-10T07:38:30Z
dc.date.issued2004
dc.description.abstractUltrastructural alterations in the liver and kidney of 3-month-old white sea bass, Lates calcarifer, after cadmium exposure were studied by transmission electron microscopy (TEM). One group of fish was exposed to a cadmium concentration of 10 mg/L (acute) for 96 h in a static system, and another group was exposed to cadmium concentrations of 0.8 and 3 mg/L cadmium (subchronic) for 3 months in a recirculation closed system. Ultrastructural alterations observed in the hepatocytes included mitochondrial condensation, swelling, and lysis. The rough endoplasmic reticulum (RER) showed dilation, fragmentation, and vesiculation. After subchronic exposure there were numerous large lipid droplets and abundant stored glycogen. Ultrastructural alterations observed in the proximal tubules of the kidney included nuclear degeneration, condensation, and massive swelling of the mitochondria; RER fragmentation and vesiculation. Disorganized brush borders and increased numbers of large hydropic vacuoles and lysosomes were also observed. © 2004 Wiley Periodicals, Inc.
dc.identifier.citationEnvironmental Toxicology
dc.identifier.doi10.1002/tox.10146
dc.identifier.issn15204081
dc.identifier.scopus2-s2.0-1242296880
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/5086
dc.languageEnglish
dc.rights.holderScopus
dc.subjectAcute exposure
dc.subjectCadmium
dc.subjectKidney
dc.subjectLates calcarifer
dc.subjectLiver
dc.subjectSubchronic exposure
dc.subjectUltrastructure
dc.titleUltrastructural alterations in the liver and kidney of white sea bass, Lates calcarifer, in acute and subchronic cadmium exposure
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-1242296880&doi=10.1002%2ftox.10146&partnerID=40&md5=dc77b9c566b9fbb4bbd4af06a550dc18
oaire.citation.endPage19
oaire.citation.issue1
oaire.citation.startPage11
oaire.citation.volume19
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