In vitro Antioxidant, Anti-Inflammatory, and Wound Healing Properties of Aloe Vera Infused with Canola Oil for Possible Application in Skin Cosmetics

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dc.contributor.authorKhwunjit itsarasook
dc.contributor.authorPiyanuch Prompamorn
dc.contributor.authorJittarawadee Tanghiranrat
dc.contributor.authorAmornrat Srisukong
dc.contributor.authorOrapin Komutiban
dc.contributor.authorWoraphot Haritakun
dc.contributor.authorKanlayaporn Chantree
dc.date.accessioned2025-09-15T09:24:48Z
dc.date.available2025-09-15T09:24:48Z
dc.date.issued2025-04-25
dc.description.abstractThis research investigates the antioxidant, anti-inflammatory, and woundhealing properties of Aloe vera oil, along with its cytotoxic effects on normal human dermal fibroblasts (NHDF), particularly in the context of its potential use as a natural antioxidant in skincare formulations. A. vera oil was extracted using an infusion method with canola oil, and its properties were thorough characterized. The concentration of aloin and cycloartenol in the A. vera oil were measured using high-performance liquid chromatography (HPLC). The resulted indicated that A. vera oil exhibited no cytotoxicity towards NHDF cells. Additionally, the oil demonstrated antioxidant activity, as evidenced by its ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, and its reducing potential assessed through free radical scavenging activity (FRAP) assays. Regarding its anti-inflammatory properties, the A. vera oil at a specific concentration showed no cytotoxic effects on RAW 264.7 macrophage cells. Notably, its potent anti-inflammatory effects significantly (p<0.05) reduced nitric oxide (NO) productions in RAW 264.7 macrophage cells stimulated by lipopolysaccharide (LPS), compared to the LPS-treated cells group. Moreover, NHDF cells treated with A. vera oil exhibited a statistically significant (p<0.05) improvement in wound closure area in a scratch wound assay, indicating enhanced cell migration. Collectively, these findings highlight the antioxidant, anti-inflammatory, and wound-healing properties of A. vera oil, underscoring its potential as an eco-friendly and beneficial ingredient for cosmetic skincare products.
dc.description.sponsorshipResearch and Development Institute
dc.identifier.issn2630-0311
dc.identifier.urihttps://repository.dusit.ac.th/handle/123456789/12944
dc.language.isoen
dc.publisherGraphicsite 295 Nakhon Ratchasima Road, Dusit, Bangkok, Thailand 10300
dc.relation.ispartofseriesVol. 18 No. 1 (2025): January - April; -
dc.subjectAloe vera oil
dc.subjectAntioxidant
dc.subjectAnti-inflammatory
dc.subjectWound healing
dc.subjectSkin cosmetic
dc.titleIn vitro Antioxidant, Anti-Inflammatory, and Wound Healing Properties of Aloe Vera Infused with Canola Oil for Possible Application in Skin Cosmetics
dc.typeArticle
mods.location.urlhttps://li01.tci-thaijo.org/index.php/sdust/article/view/265619/179997
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