Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation

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dc.contributor.authorN. Suwannateep
dc.contributor.authorS. Wanichwecharungruang
dc.contributor.authorS.F. Haag
dc.contributor.authorS. Devahastin
dc.contributor.authorN. Groth
dc.contributor.authorJ.W. Fluhr
dc.contributor.authorJ. Lademann
dc.contributor.authorM.C. Meinke
dc.contributor.correspondenceM.C. Meinke; CharitŽ-UniversitŠtsmedizin Berlin, Center of Experimental and Applied Cutaneous Physiology, 10117 Berlin, CharitŽplatz 1, Germany; email: martina.meinke@charite.de
dc.date.accessioned2025-03-10T07:37:40Z
dc.date.available2025-03-10T07:37:40Z
dc.date.issued2012
dc.description.abstractThe phytochemical curcumin possesses antioxidant activity; however, it becomes unstable after being exposed to light or heat or loses activity during storage. This is especially important when curcumin is applied to the skin within a cosmetic or pharmaceutical formulation, since sun exposure is unavoidable. This drawback can be directly addressed by encapsulation of curcumin in photo-stable nanospheres. Therefore, curcumin was encapsulated into nanoparticles consisting of ethyl cellulose and/or methyl cellulose. Nanoparticles were subjected to processing conditions commonly used in industry, for example, temperature and pressure and thus retained their morphology. Furthermore, sun exposure resulted in the protection of curcumin by nanoparticles, whereas non-encapsulated curcumin degraded completely. Determination of the radical protection factor resulted in similar antioxidant activity of encapsulated and non-encapsulated curcumin indicating that curcumin maintains its antioxidant activity. Application of lotions containing curcumin or curcumin nanoparticles to the skin and subsequent UVB-irradiation resulted in less radical formation compared to lotion application only. Moreover, radical formation was even less after nanoparticle application compared to free curcumin. Nanoencapsulation protects curcumin from photo degradation and can therefore prolong the antioxidant activity of curcumin. © 2012 Elsevier B.V. All rights reserved.
dc.identifier.citationEuropean Journal of Pharmaceutics and Biopharmaceutics
dc.identifier.doi10.1016/j.ejpb.2012.08.010
dc.identifier.issn18733441
dc.identifier.scopus2-s2.0-84870507106
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/5000
dc.languageEnglish
dc.rights.holderScopus
dc.subjectAntioxidant
dc.subjectCurcumin
dc.subjectElectron paramagnetic resonance
dc.subjectFree radical
dc.subjectPhoto degradation
dc.subjectSkin
dc.titleEncapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84870507106&doi=10.1016%2fj.ejpb.2012.08.010&partnerID=40&md5=61ebc796c28b1b31c7e1d677be99a09a
oaire.citation.endPage490
oaire.citation.issue3
oaire.citation.startPage485
oaire.citation.volume82
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