In-vitro drug release activity from core/shell electrospun mats of sPLA-CPEG/GS and sPLA/CA-CPEG/GS

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dc.contributor.authorKoravee Vichitchote
dc.contributor.authorPoonsub Threepopnatkul
dc.contributor.authorSupakij Suttiruengwong
dc.contributor.authorChanin Kulsetthanchalee
dc.contributor.correspondenceP. Threepopnatkul; Department of Materials Science and Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Nakhon Pathom 73000, Thailand; email: poonsubt@yahoo.com
dc.date.accessioned2025-03-10T07:37:40Z
dc.date.available2025-03-10T07:37:40Z
dc.date.issued2012
dc.description.abstractIn this research, the core-shell structured fiber was fabricated by coaxial electrospinning technique. A set of biodegradable polymers namely polylactic acid (PLA) and cellulose acetate (CA) were used as the shell material. Gentamicin sulfate (GS) as antimicrobial drug with polyethylene glycol (PEG) was used as the core structure. PEG formed the core section of the core-shell fibers for GS encapsulation. In-vitro drug release activity of the core-shell fibers was determined by total immersion method in pH 7.4 phosphate buffer solutions (PBS). It was found that core-shell fibers sPLA-cPEG/GS exhibit higher initial release compared to that of core-shell fibers sPLA/CAcPEG/ GS. © (2012) Trans Tech Publications, Switzerland.
dc.identifier.citationMaterials Science Forum
dc.identifier.doi10.4028/www.scientific.net/MSF.714.263
dc.identifier.isbn978-303785383-2
dc.identifier.issn2555476
dc.identifier.scopus2-s2.0-84859731553
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/4979
dc.languageEnglish
dc.publisherTrans Tech Publications Ltd
dc.rights.holderScopus
dc.subjectCellulose acetate
dc.subjectElectrospinning
dc.subjectGentamicin
dc.subjectPEG
dc.subjectPLA
dc.titleIn-vitro drug release activity from core/shell electrospun mats of sPLA-CPEG/GS and sPLA/CA-CPEG/GS
dc.typeConference paper
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84859731553&doi=10.4028%2fwww.scientific.net%2fMSF.714.263&partnerID=40&md5=a376a01ff3da3140eff83e3c32b3ede1
oaire.citation.endPage270
oaire.citation.startPage263
oaire.citation.volume714
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