Comparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration

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dc.contributor.authorN. Suwannateep
dc.contributor.authorS. Wanichwecharungruang
dc.contributor.authorJ. Fluhr
dc.contributor.authorA. Patzelt
dc.contributor.authorJ. Lademann
dc.contributor.authorM.C. Meinke
dc.contributor.correspondenceM.C. Meinke; Center of Experimental Applied Cutaneous Physiology, Department of Dermatology and Allergology, CharitŽ - UniversitŠtsmedizin Berlin, 10117 Berlin, CharitŽplatz 1, Germany; email: martina.meinke@charite.de
dc.date.accessioned2025-03-10T07:37:40Z
dc.date.available2025-03-10T07:37:40Z
dc.date.issued2013
dc.description.abstractBackground: Curcumin is known for its anti-inflammatory, antioxidative, and anticarcinogenic properties. However, the strong lipophilic compound is not easily applicable, neither in water, nor directly in o/w formulations. So far, loading of nano or micro scaled carriers has enabled only an uptake up to 30% of curcumin. Method: In the present article, curcumin was successfully encapsulated into two different safe and inexpensive polymers, ethyl cellulose and methyl cellulose blended ethyl cellulose with a loading capacity of ~ 46-48%. In addition, the in vitro skin penetration of the two curcumin encapsulated particular systems, which were applied each in three different formulations, an o/w, w/o lotion, and water suspension, was investigated on porcine ear skin using Laser scanning microscopy. Results: It was found that in comparison to water suspensions, o/w and w/o lotions enhanced, especially the follicular penetration of the encapsulated curcumin particles into porcine skin, whereas the w/o enhanced the penetration better than the o/w lotion. Furthermore, the application of ethyl cellulose blended with methyl cellulose improved the penetration of curcumin in all formulations. Conclusion: High loaded encapsulated curcumin systems, prepared from a simple and highly efficient encapsulation system can be used to transport curcumin effectively into the skin. © 2011 John Wiley & Sons A/S.
dc.identifier.citationSkin Research and Technology
dc.identifier.doi10.1111/j.1600-0846.2011.00600.x
dc.identifier.issn16000846
dc.identifier.scopus2-s2.0-84872169344
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/4969
dc.languageEnglish
dc.rights.holderScopus
dc.subjectEthyl cellulose
dc.subjectHair follicle
dc.subjectLaser scanning microscopy
dc.subjectMethyl cellulose
dc.subjectPenetration depths
dc.titleComparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84872169344&doi=10.1111%2fj.1600-0846.2011.00600.x&partnerID=40&md5=27dc01480d68893dc945e38e62c0a8f5
oaire.citation.endPage9
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.volume19
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