Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients

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dc.contributor.authorPensri Saelee
dc.contributor.authorUbol Chuensumran
dc.contributor.authorSopit Wongkham
dc.contributor.authorSunanta Chariyalertsak
dc.contributor.authorDanai Tiwawech
dc.contributor.authorSongsak Petmitr
dc.contributor.correspondenceP. Saelee; Research Division, National Cancer Institute, Bangkok, Thailand; email: saelee@health.moph.go.th
dc.date.accessioned2025-03-10T07:37:40Z
dc.date.available2025-03-10T07:37:40Z
dc.date.issued2012
dc.description.abstractHepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. The aim of this study was to determine whether aberrant methylation of the suppressor of cytokine signaling 1 gene (SOCS1) occurs in HCCs. Methylation specific-PCR assays were performed to identify the methylation status of SOCS1 in 29 tumors and their corresponding normal liver tissues. An abnormal methylation status was detected in 17 (59%), with a higher prevalence of aberrant SOCS1 methylation significantly correlating with HCC treated without chemotherapy (OR=0.04, 95%CI=0.01-0.31; P=0.001). This study suggests that epigenetic aberrant SOCS1 methylation may be a predictive marker for HCC patients.
dc.identifier.citationAsian Pacific Journal of Cancer Prevention
dc.identifier.doi10.7314/APJCP.2012.13.7.3489
dc.identifier.issn15137368
dc.identifier.scopus2-s2.0-84873628694
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/5007
dc.languageEnglish
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.rightsAll Open Access; Gold Open Access
dc.rights.holderScopus
dc.subjectDNA methylation
dc.subjectHepatocellular carcinoma
dc.subjectMethylation-specific PCR
dc.subjectSOCS1
dc.titleHypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84873628694&doi=10.7314%2fAPJCP.2012.13.7.3489&partnerID=40&md5=ee75fa6d23b0e31a6884d56e8538c18d
oaire.citation.endPage3493
oaire.citation.issue7
oaire.citation.startPage3489
oaire.citation.volume13
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