Stephapierrines A-H, new tetrahydroprotoberberine and aporphine alkaloids from the tubers of: Stephania pierrei Diels and their anti-cholinesterase activities

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dc.contributor.authorWaraluck Chaichompoo
dc.contributor.authorPornchai Rojsitthisak
dc.contributor.authorWachirachai Pabuprapap
dc.contributor.authorYuttana Siriwattanasathien
dc.contributor.authorPathumwadee Yotmanee
dc.contributor.authorWoraphot Haritakun
dc.contributor.authorApichart Suksamrarn
dc.contributor.correspondenceP. Rojsitthisak; Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand; email: pornchai.r@chula.ac.th
dc.date.accessioned2025-03-10T07:35:29Z
dc.date.available2025-03-10T07:35:29Z
dc.date.issued2021
dc.description.abstractEight new alkaloids, which are four new tetrahydroprotoberberine alkaloids, stephapierrines A-D (1-4), and four new aporphine alkaloids, stephapierrines E-H (5-8), together with three new naturally occurring alkaloids (9-11) and thirty-four known alkaloids (12-45) were isolated from the tubers of Stephania pierrei Diels. The structures of the new compounds were elucidated by spectroscopic analysis and physical properties. The structures of the known compounds were characterized by comparison of their spectroscopic data with those previously reported. Compound 42 exhibited the strongest acetylcholinesterase (AChE) inhibitory activity, which was more active than galanthamine, the reference drug. Compound 23 showed the highest butyrylcholinesterase (BuChE) inhibitory activity, which was also more active than galanthamine. Molecular docking studies are in good agreement with the experimental results. This journal is © The Royal Society of Chemistry.
dc.identifier.citationRSC Advances
dc.identifier.doi10.1039/d1ra03276c
dc.identifier.issn20462069
dc.identifier.scopus2-s2.0-85108715764
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/4722
dc.languageEnglish
dc.publisherRoyal Society of Chemistry
dc.rightsAll Open Access; Green Open Access
dc.rights.holderScopus
dc.titleStephapierrines A-H, new tetrahydroprotoberberine and aporphine alkaloids from the tubers of: Stephania pierrei Diels and their anti-cholinesterase activities
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85108715764&doi=10.1039%2fd1ra03276c&partnerID=40&md5=984e8d5fa07e7b7cb668e8c39be19bac
oaire.citation.endPage21169
oaire.citation.issue34
oaire.citation.startPage21153
oaire.citation.volume11
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