Sequential green extraction, identification, and encapsulation of bioactive compound from Phellinus linteus fruiting body

Simple item page
dc.contributor.authorTita Foophow
dc.contributor.authorSittiruk Roytrakul
dc.contributor.authorVilai Rungsardthong
dc.contributor.authorWeerachon Phoohinkong
dc.contributor.correspondenceW. Phoohinkong; Faculty of Science and Technology, Suan Dusit University, Bangkok, 10300, Thailand; email: weerachon_pho@dusit.ac.th
dc.date.accessioned2025-03-10T07:22:48Z
dc.date.available2025-03-10T07:22:48Z
dc.date.issued2025
dc.description.abstractPhellinus linteus, a traditional medicinal mushroom, is highly valued for its health benefits. The commercially available fruiting body of Phellinus linteus (PL) was extracted and characterized to elucidate its potential nutritional bioactivity. A sequential extraction method was employed, starting with conventional ethanol extraction (PL-E), followed by mechanical ball-mill assisted ethanol extraction (PL-B) or supercritical CO2 cosolvent (PL-C), resulting in the identification of 19, 9, and 10 tentative compounds, respectively. The extracts comprised non-polar compounds, including triterpenoids and sterols in PL-E, and polyphenols and long-chain fatty acids in PL-B and PL-C. Hispidin and hispolon were found exclusively in PL-E. The PL-E demonstrated anticancer potential against MCF-7 cells, while the PL-C showed the highest activity against MCF-7 and HT-29 cells, suggesting that this high bioactivity fraction may be a promising candidate for anticancer studies. The PL-E, which exhibited high yield and bioactivity with various bioactive compounds, underwent complexation encapsulation with _-cyclodextrin. This study also proposes a potential green method to enhance these compounds' bioactivity value and bioaccessibility, supporting their development for food, nutraceutical, and pharmacological applications. © 2025
dc.identifier.citationResults in Chemistry
dc.identifier.doi10.1016/j.rechem.2025.102112
dc.identifier.issn22117156
dc.identifier.scopus2-s2.0-85217928376
dc.identifier.urihttps://repository.dusit.ac.th//handle/123456789/4438
dc.languageEnglish
dc.publisherElsevier B.V.
dc.rightsAll Open Access; Gold Open Access
dc.rights.holderScopus
dc.subjectAnticancer
dc.subjectEncapsulation
dc.subjectMushroom
dc.subjectPhellinus
dc.subjectSupercritical CO<sub>2</sub>
dc.titleSequential green extraction, identification, and encapsulation of bioactive compound from Phellinus linteus fruiting body
dc.typeArticle
mods.location.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85217928376&doi=10.1016%2fj.rechem.2025.102112&partnerID=40&md5=9069de991c47a6dec479d9c5581f0c9b
oaire.citation.volume14
Files
Collections
SCOPUS 2025