SCOPUS 2010-2014

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Browsing SCOPUS 2010-2014 by Subject "Antioxidant"

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    Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation
    (2012) N. Suwannateep; S. Wanichwecharungruang; S.F. Haag; S. Devahastin; N. Groth; J.W. Fluhr; J. Lademann; M.C. Meinke; M.C. Meinke; CharitŽ-UniversitŠtsmedizin Berlin, Center of Experimental and Applied Cutaneous Physiology, 10117 Berlin, CharitŽplatz 1, Germany; email: martina.meinke@charite.de
    The phytochemical curcumin possesses antioxidant activity; however, it becomes unstable after being exposed to light or heat or loses activity during storage. This is especially important when curcumin is applied to the skin within a cosmetic or pharmaceutical formulation, since sun exposure is unavoidable. This drawback can be directly addressed by encapsulation of curcumin in photo-stable nanospheres. Therefore, curcumin was encapsulated into nanoparticles consisting of ethyl cellulose and/or methyl cellulose. Nanoparticles were subjected to processing conditions commonly used in industry, for example, temperature and pressure and thus retained their morphology. Furthermore, sun exposure resulted in the protection of curcumin by nanoparticles, whereas non-encapsulated curcumin degraded completely. Determination of the radical protection factor resulted in similar antioxidant activity of encapsulated and non-encapsulated curcumin indicating that curcumin maintains its antioxidant activity. Application of lotions containing curcumin or curcumin nanoparticles to the skin and subsequent UVB-irradiation resulted in less radical formation compared to lotion application only. Moreover, radical formation was even less after nanoparticle application compared to free curcumin. Nanoencapsulation protects curcumin from photo degradation and can therefore prolong the antioxidant activity of curcumin. © 2012 Elsevier B.V. All rights reserved.
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    Preparation of zingiber officinale extract loaded solid lipid nanoparticles
    (2012) N. Ratcharin; P. Wongtrakul; R. Indranupakorn; N. Ratcharin; Faculty of Science and Technology, Suan Dusit University, Bangplad, Bangkok 10700, Thailand; email: new_naphutsorn@hotmail.com
    Solid lipid nanoparticles (SLNs) loaded ginger extract were prepared by microemulsion technique. The nanoparticles were composed of stearic acid as solid lipids, Cremophor RH 40 as surfactant and ethanol as co-surfactant. It was found that variation in the amount of surfactant and co-surfactant had profound effects on the mean particle size, the drug entrapment efficiency and loading capacity. Transmission electron microscope (TEM) revealed the spherical nature of the particles. The mean particle size of SLNs ranging between 453.1 and 551.7 nm were measured by dynamic light scattering (DLS). The entrapment efficiency (EE) and drug loading capacity (LC) determined by high performance liquid chromatography (HPLC) found to be in the range of 85.23-90.07% and 1.41-1.49%, respectively. © (2012) Trans Tech Publications.