Browsing by Author "Ubol Chuensumran"
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Item Aphrodisiac Food Ingredients from the Twelve Thai Ancient Formulary Books of Police Captain Bhiam Bunyachot(Research and Development Institute Suan Dusit University, 2020) Vadhana Jayathavaj; Ubol Chuensumran; V. Jayathavaj; Thai Traditional Medicine Program, Pathumthani University, Pathumthani, 10200, Thailand; email: vadhana.j@ptu.ac.thAn aphrodisiac is defined as any food or drug that arouses the sexual instinct, induces venereal desire and increases pleasure and performance. There are many commercial advertisements related to herbal supplements that claim to have an aphrodisiac property. But the claims almost always come from the long-standing belief or traditional wisdom (Chinese or Ayurveda) with no scientific support. To support Òfood is medicineÓ, the aphrodisiac herbs from Thai ancient drugs were explored from private formulary books. The properties of aphrodisiac formulas in the formulary texts were classified into four groups as follows: 1) anti-aging, 2) physical strength and power, 3) healthy sex, and 4) relief from erectile dysfunction. The herbs that appears in Thai foods in everyday life with claimed medication results from the formulary textbooks were identified. They were 49 food ingredients from 143 herbs presented in 62 aphrodisiac formulas. The herbs with herbal aphrodisiac groups (1 and 2 and 3 and 4) were ranked by the number of times they appeared thusly; Pepper, Galingale (Finger root), Ginger, Long pepper, and Nutmeg. The paper correlates the herbal foods traditionally used aphrodisiacs with recent scientific validation for the management of sexual health. © 2020, Research and Development Institute Suan Dusit University. All rights reserved.Item Aphrodisiac Food Ingredients from the Twelve Thai Ancient Formulary Books of Police Captain Bhiam Bunyachot(Graphicsite, 2023-09-26) Vadhana Jayathavaj; Ubol ChuensumranAn aphrodisiac is defined as any food or drug that arouses the sexual instinct, induces venereal desire and increases pleasure and performance. There are many commercial advertisements related to herbal supplements that claim to have an aphrodisiac property. But the claims almost always come from the long-standing belief or traditional wisdom (Chinese or Ayurveda) with no scientific support. To support “food is medicine”, the aphrodisiac herbs from Thai ancient drugs were explored from private formulary books. The properties of aphrodisiac formulas in the formulary texts were classified into four groups as follows: 1) anti-aging, 2) physical strength and power, 3) healthy sex, and 4) relief from erectile dysfunction. The herbs that appears in Thai foods in everyday life with claimed medication results from the formulary textbooks were identified. They were 49 food ingredients from 143 herbs presented in 62 aphrodisiac formulas. The herbs with herbal aphrodisiac groups (1 and 2 and 3 and 4) were ranked by the number of times they appeared thusly; Pepper, Galingale (Finger root), Ginger, Long pepper, and Nutmeg. The paper correlates the herbal foods traditionally used aphrodisiacs with recent scientific validation for the management of sexual health.Item Correlating the Speed of Sound with the Gibbs Energy and Estimating the Speed of Sound in Fatty Acid Methyl Ester and Biodiesel(John Wiley and Sons Inc, 2021) Apinya Cheewaphan; Ubol Chuensumran; Suriya Phankosol; Kornkanok Aryusuk; Supathra Lilitchan; Kanit Krisnangkura; K. Krisnangkura; Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi (Bangkhuntien), Bangkok, 10150, Thailand; email: kanitkrsnk@yahoo.comThe relationship between the speed of sound (u) in biodiesel and the change in Gibbs energy (_G) has not been described in the literature. With the Gibbs energy additivity method, the relationship between u and _G can be expressed as ln(u2)Ê=Ê_G/RT + A, where R is the universal gas constant, T is the absolute temperature, and A is a constant. The molecule of fatty acid methyl ester (FAME) was arbitrarily sub-divided into groups of atoms and a _G was assigned to each group of atoms. A new model correlating the speed of sound to the structure of fatty acid was derived. The proposed model was good for estimation of the speed of sound in both FAME and biodiesel at various temperatures with good accuracy. The absolute average deviations for the speed of sound in FAME (65 data points) and in biodiesel (175 data points) were 0.23% and 0.36%, respectively. Only the number of double bonds and carbon atoms of the fatty acid are required for the calculation. © 2021 AOCSItem Crisp Bhutan Oyster Mushroom (Pleurotus pulmonarius): A Potential Innovative Product for Commercialization(Research and Development Institute Suan Dusit University, 2022) Ubol Chuensumran; Att Khunsee; A. Khunsee; School of Culinary Arts, Suan Dusit University, Lampang Center, Lampang, 52100, Thailand; email: Att_khu@dusit.ac.thThis research was undertaken to create therapeutic mushroom products and disseminate knowledge to entrepreneurs. The researchers along with a community created product design and distribution channels and developed a brand for medicinal mushroom products based on the community's identity. Bhutanese oyster mushrooms were used to create mushroom products that consisted of Bhutanese oyster mushroom (88%), sugar (5%), vegetable oil (3%), soy sauce (2%), coriander seeds (1%) and salt (1%).The production method was conducted by to washing the mushrooms thoroughly, squeezing the water out and setting them aside; then mixing all ingredients together and dry in a hot air oven at 60¡C for 90 min. Then the batter was fried in hot oil at 90-95¡C for 5 min, and then placed in the oven at 150¡C for 20 min to crisp and reduce the surface moisture of the product. The sensory preference (7.80 Ð 8.80 points) was at a high level. Moreover, the knowledge can be transferred to entrepreneurs to implement in real production. It is a product that has the potential to be marketed for distribution as a health food with an emphasis on semi-premium marketing which can be differentiated by demonstrating the value and nutrients of Bhutanese oyster mushrooms. This research included designing aesthetic, outstanding and unique packaging to create the identity for the community. Furthermore, a brand of medicinal mushroom products called ÒHed Khik Khak or Giggling MushroomsÓ was created. The feedback acceptance (99%) was at a high level. The product has been registered under the trademark for Klong Chik Sub-district Community Enterprise to be used with therapeutic mushroom products in the future. © 2022, Research and Development Institute Suan Dusit University. All rights reserved.Item Crisp Bhutan Oyster Mushroom (Pleurotus pulmonarius): A Potential Innovative Product for Commercialization(Journal of Food Health and Bioenvironmental Science. Vol. 15 No. 3 September - December 2022., 2023-09-26) Ubol Chuensumran; Att KhunseeThis research was undertaken to create therapeutic mushroom products and disseminate knowledge to entrepreneurs. The researchers along with a community created product design and distribution channels and developed a brand for medicinal mushroom products based on the community's identity. Bhutanese oyster mushrooms were used to create mushroom products that consisted of Bhutanese oyster mushroom (88%), sugar (5%), vegetable oil (3%), soy sauce (2%), coriander seeds (1%) and salt (1%).The production method was conducted by to washing the mushrooms thoroughly, squeezing the water out and setting them aside; then mixing all ingredients together and dry in a hot air oven at 60°C for 90 min. Then the batter was fried in hot oil at 90-95°C for 5 min, and then placed in the oven at 150°C for 20 min to crisp and reduce the surface moisture of the product. The sensory preference (7.80 – 8.80 points) was at a high level. Moreover, the knowledge can be transferred to entrepreneurs to implement in real production. It is a product that has the potential to be marketed for distribution as a health food with an emphasis on semi-premium marketing which can be differentiated by demonstrating the value and nutrients of Bhutanese oyster mushrooms. This research included designing aesthetic, outstanding and unique packaging to create the identity for the community. Furthermore, a brand of medicinal mushroom products called “Hed Khik Khak or Giggling Mushrooms” was created. The feedback acceptance (99%) was at a high level. The product has been registered under the trademark for Klong Chik Sub-district Community Enterprise to be used with therapeutic mushroom products in the future.Item Crisp Bhutan Oyster Mushroom (Pleurotus pulmonarius): A Potential Innovative Product for Commercialization(Graphicsite, 2023-09-26) Ubol Chuensumran; Att KhunseeThis research was undertaken to create therapeutic mushroom products and disseminate knowledge to entrepreneurs. The researchers along with a community created product design and distribution channels and developed a brand for medicinal mushroom products based on the community's identity. Bhutanese oyster mushrooms were used to create mushroom products that consisted of Bhutanese oyster mushroom (88%), sugar (5%), vegetable oil (3%), soy sauce (2%), coriander seeds (1%) and salt (1%).The production method was conducted by to washing the mushrooms thoroughly, squeezing the water out and setting them aside; then mixing all ingredients together and dry in a hot air oven at 60°C for 90 min. Then the batter was fried in hot oil at 90-95°C for 5 min, and then placed in the oven at 150°C for 20 min to crisp and reduce the surface moisture of the product. The sensory preference (7.80 – 8.80 points) was at a high level. Moreover, the knowledge can be transferred to entrepreneurs to implement in real production. It is a product that has the potential to be marketed for distribution as a health food with an emphasis on semi-premium marketing which can be differentiated by demonstrating the value and nutrients of Bhutanese oyster mushrooms. This research included designing aesthetic, outstanding and unique packaging to create the identity for the community. Furthermore, a brand of medicinal mushroom products called “Hed Khik Khak or Giggling Mushrooms” was created. The feedback acceptance (99%) was at a high level. The product has been registered under the trademark for Klong Chik Sub-district Community Enterprise to be used with therapeutic mushroom products in the future.Item Histological type of intrahepatic cholangiocarcinoma differentiated by genetic alteration from AP-PCR fingerprint(Asian Pacific Organization for Cancer Prevention, 2011) Ubol Chuensumran; Pensri Saelee; Sopit Wongkham; Chawalit Pairojkul; Siri Chauin; Songsak Petmitr; U. Chuensumran; Department of Chemistry, Faculty of Science and Technology, Rajabhat University Suan Dusit, Bangkok, Thailand; email: ubolc@yahoo.comCholangiocarcinoma (CCA), the malignant neoplasm of the biliary epithelium, is usually fatal due to difficulty in early diagnosis and lack of availability of effective therapy. The genetic mechanisms involved in the development of CCA are not well understood and only a few cytogenetic studies have been published. In this study, genomic instability in 30 Thai cases of intrahepatic cholangiocarcinoma (ICC) was assessed using an arbitrarily primed- polymerase chain reaction (AP-PCR) method. Genetic alterations were analyzed as banding pattern changes between tumors and corresponding normal DNA. The abnormal band present at the highest frequency (23/30 cases, 77%) appeared with the AO16 primer. Statistical analysis also showed that DNA alteration from this primer was significantly associated with the moderately to poorly differentiated histological type (P = 0.038). Kaplan-Meier survival curves showed borderline significance for this DNA aberration (P = 0.06 by the log-rank test). This DNA fragment may thus be of use to predict degree of malignancy of the disease.Item Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients(Asian Pacific Organization for Cancer Prevention, 2012) Pensri Saelee; Ubol Chuensumran; Sopit Wongkham; Sunanta Chariyalertsak; Danai Tiwawech; Songsak Petmitr; P. Saelee; Research Division, National Cancer Institute, Bangkok, Thailand; email: saelee@health.moph.go.thHepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. The aim of this study was to determine whether aberrant methylation of the suppressor of cytokine signaling 1 gene (SOCS1) occurs in HCCs. Methylation specific-PCR assays were performed to identify the methylation status of SOCS1 in 29 tumors and their corresponding normal liver tissues. An abnormal methylation status was detected in 17 (59%), with a higher prevalence of aberrant SOCS1 methylation significantly correlating with HCC treated without chemotherapy (OR=0.04, 95%CI=0.01-0.31; P=0.001). This study suggests that epigenetic aberrant SOCS1 methylation may be a predictive marker for HCC patients.Item RASSF1A promoter hypermethylation as a prognostic marker for hepatocellular carcinoma(Asian Pacific Organization for Cancer Prevention, 2010) Pensri Saelee; Sopit Wongkham; Sunanta Chariyalertsak; Songsak Petmitr; Ubol Chuensumran; P. Saelee; Research Division, National Cancer Institute, Bangkok, Thailand; email: saelee@health.moph.go.thThis study was performed to determine whether epigenetic aberrant methylation of RASSF1A might be associated with hepatocarcinogenesis. Methylation specific-PCR was performed to identify RASSF1A promoter hypermethylation in 29 tumors and corresponding normal liver tissues. In addition, RASSF1A mRNA levels were analyzed by quantitative real-time reverse transcription-PCR. Aberrant methylation of RASSF1A was detected in 25 of 29 cases (86%), with loss of RASSF1A expression evident in 8 of 22 cases (36%). No correlation between loss of RASSF1A mRNA and promoter hypermethylation of the RASSF1A gene was observed. There was a significant correlation between the methylation status of RASSF1A and hepatocellular carcinoma (HCC) patients who did not undergo chemotherapy (P = 0.03). Multivariate analysis, adjusted for tumor size, treatment, RASSF1A hypermethylation, and RASSF1A under-expression, showed RASSF1A hypermethylation to be assocaited with a better prognosis for HCC patients (HR= 0.089, 95%CI = 0.013-0.578; P = 0.012). Our findings showed that RASSF1A promoter hypermethylation occurs frequently, and may serve as a good prognostic factor.Item Small rna interference inhibition of ubiquitin-specific protease 14 gene expression in intrahepatic cholangiocarcinoma primary cells(SEAMEO TROPMED Network, 2020) Ubol Chuensumran; Tasanee Panichakul; Thun Ingkakul; Poom Adisakwattana; U. Chuensumran; Department of Food Processing Technology, School of Culinary Arts, Suan Dusit University, Bangkok, 10300, Thailand; email: ubol_chu@dusit.ac.thStudies on genomic instabilities of intrahepatic cholangiocarcinoma (ICC) from Thai patients have shown 52% variations in a specific region of ubiquitin-specific protease 14 gene (USP14) located on 18p11.32. Inhibition of USP14 expression in three different primary cells cultured from resected ICC tissues by transfecting with double-strand RNA interference targeting exon 16 region of USP14 mRNA resulted in 6-50% reduction in mRNA levels, with cells with low USP14 expression being more affected. These findings lend support to a potential in developing strategies against USP14 in ICC. © 2020, SEAMEO TROPMED Network. All rights reserved.Item Ubiquitin-specific protease 14 expression associated with intrahepatic cholangiocarcinoma cell differentiation(Asian Pacific Organization for Cancer Prevention, 2011) Ubol Chuensumran; Pensri Saelee; Phaibul Punyarit; Sopit Wongkham; Chawalit Pairojkul; Siri Chauin; Songsak Petmitr; U. Chuensumran; Department of Chemistry, Faculty of Science and Technology, Rajabhat University Suan Dusit, Thailand; email: ubol_c@yahoo.comThe purpose of this study was to identify the gene alterations amplified from AO16 primer and examine whether the expression patterns of USP14 in clinical specimens from patients with intrahepatic cholangiocarcinoma (ICC) is associated with cancer cells. DNA from tumor and corresponding normal tissues of 52 patients was amplified with 33 arbitrary primers. The DNA fragment that altered most frequently in ICC was cloned, sequenced, and identified by comparison with known nucleotide sequences in the genome database. The DNA copy numbers of the allelic alterations in cholangiocarcinoma were determined by quantitative real-time PCR and interpreted as allelic loss or DNA amplification by comparison with the reference gene. Associations between allelic imbalance and clinicopathological parameters of ICC patients were evaluated by _2-tests. The Kaplan-Meier method was used to analyze survival rates. Immunohistochemically, USP14 showed weak cytoplasmic staining in normal bile duct epithelial cells. It was strongly detected in 21 cancer patients (43.8%). There were correlations between USP14 expression level and the clinicopathological features of ICC, histological grade (P < 0.05). However, there were no significant differences in age, gender, tumor size, metastasis, lymph node metastasis, and staging. USP14 expression was related to cholangiocarcinoma cell differentiation. Due to their emerging role in control of multiple signaling pathways and oncoproteins, USP14 inhibitors may be useful for anticancer agents.