Browsing by Author "S. Wanichwecharungruang"

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    Comparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration
    (2013) N. Suwannateep; S. Wanichwecharungruang; J. Fluhr; A. Patzelt; J. Lademann; M.C. Meinke; M.C. Meinke; Center of Experimental Applied Cutaneous Physiology, Department of Dermatology and Allergology, CharitŽ - UniversitŠtsmedizin Berlin, 10117 Berlin, CharitŽplatz 1, Germany; email: martina.meinke@charite.de
    Background: Curcumin is known for its anti-inflammatory, antioxidative, and anticarcinogenic properties. However, the strong lipophilic compound is not easily applicable, neither in water, nor directly in o/w formulations. So far, loading of nano or micro scaled carriers has enabled only an uptake up to 30% of curcumin. Method: In the present article, curcumin was successfully encapsulated into two different safe and inexpensive polymers, ethyl cellulose and methyl cellulose blended ethyl cellulose with a loading capacity of ~ 46-48%. In addition, the in vitro skin penetration of the two curcumin encapsulated particular systems, which were applied each in three different formulations, an o/w, w/o lotion, and water suspension, was investigated on porcine ear skin using Laser scanning microscopy. Results: It was found that in comparison to water suspensions, o/w and w/o lotions enhanced, especially the follicular penetration of the encapsulated curcumin particles into porcine skin, whereas the w/o enhanced the penetration better than the o/w lotion. Furthermore, the application of ethyl cellulose blended with methyl cellulose improved the penetration of curcumin in all formulations. Conclusion: High loaded encapsulated curcumin systems, prepared from a simple and highly efficient encapsulation system can be used to transport curcumin effectively into the skin. © 2011 John Wiley & Sons A/S.
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    Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation
    (2012) N. Suwannateep; S. Wanichwecharungruang; S.F. Haag; S. Devahastin; N. Groth; J.W. Fluhr; J. Lademann; M.C. Meinke; M.C. Meinke; CharitŽ-UniversitŠtsmedizin Berlin, Center of Experimental and Applied Cutaneous Physiology, 10117 Berlin, CharitŽplatz 1, Germany; email: martina.meinke@charite.de
    The phytochemical curcumin possesses antioxidant activity; however, it becomes unstable after being exposed to light or heat or loses activity during storage. This is especially important when curcumin is applied to the skin within a cosmetic or pharmaceutical formulation, since sun exposure is unavoidable. This drawback can be directly addressed by encapsulation of curcumin in photo-stable nanospheres. Therefore, curcumin was encapsulated into nanoparticles consisting of ethyl cellulose and/or methyl cellulose. Nanoparticles were subjected to processing conditions commonly used in industry, for example, temperature and pressure and thus retained their morphology. Furthermore, sun exposure resulted in the protection of curcumin by nanoparticles, whereas non-encapsulated curcumin degraded completely. Determination of the radical protection factor resulted in similar antioxidant activity of encapsulated and non-encapsulated curcumin indicating that curcumin maintains its antioxidant activity. Application of lotions containing curcumin or curcumin nanoparticles to the skin and subsequent UVB-irradiation resulted in less radical formation compared to lotion application only. Moreover, radical formation was even less after nanoparticle application compared to free curcumin. Nanoencapsulation protects curcumin from photo degradation and can therefore prolong the antioxidant activity of curcumin. © 2012 Elsevier B.V. All rights reserved.