Browsing by Author "Nattapon Kaisangsri"

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    Antioxidant and anti-aging enzyme activities of bioactive compounds isolated from selected Zingiberaceae plants
    (Kasetsart University, 2021) Rittipun Rungruang; Wittawat Ratanathavorn; Nattaporn Boohuad; Orrapun Selamassakul; Nattapon Kaisangsri; R. Rungruang; Department of Cosmetic Science, Faculty of Science and Technology, Suan Dusit University, Bangkok, 10700, Thailand; email: rittipun_run@dusit.ac.th
    Bioactive compounds and antioxidant and enzyme inhibition activity levels were evaluated for three plants in the Zingiberaceae family in Thailand. Quantification of the phenolic and curcumin contents revealed that the largest component of all extracts was phenolic compounds (213.16-317.64 mg/g extract). The major curcuminoids in Curcuma longa L., Curcuma aromatica Salisb. and Zingiber montanum (J.Koenig) Link ex A.Dietr. were bisdemethoxycurcumin (BDMC; 27.31 mg/g extract), curcumin (16.59 mg/g extract), and curcumin (0.12 mg/g extract), respectively. The extracts from C. longa, C. aromatica and Z. montanum all showed antioxidant activity that was assessed using 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH¥) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS¥+) radical scavenging assay. In addition, all extracts had copper chelating activity of more than 50%, with the extract from C. longa having the highest chelating activity (76.45%). All extracts from the three plants inhibited tyrosinase and elastase activity with half maximal inhibitory concentration values of 290.33-1,373.68 µg/mL and 69.61-3386.23 µg/mL, respectively. In addition, collagenase inhibition activity was observed in all extracts. The findings from this study showed that extracts from C. longa, C. aromatica and Z. montanum have potential antioxidant activity and can act as anti-tyrosinase, anti-collagenase and anti-elastase agents. The extracts could be further applied in cosmeceuticals as an active ingredient for anti-aging products. © 2021 Elsevier B.V.. All rights reserved.
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    Effects of extraction methods on the flavonoid and phenolic contents and anti-aging properties of Rhyncholaeliocattleya Haw Yuan Beauty extracts
    (Science Society of Thailand under Royal Patronage, 2021) Rittipun Rungruang; Tasanee Panichakul; Wittawat Rattanathavorn; Nattapon Kaisangsri; Orapin Kerdchoechuen; Natta Laohakunjit; Louis Kuoping Chao; R. Rungruang; Department of Cosmetic Science, Faculty of Science and Technology, Suan Dusit University, Bangkok, 10700, Thailand; email: rittipun_run@dusit.ac.th
    Rhyncholaeliocattleya Haw Yuan Beauty (Rlc. Haw Yuan Beauty) is a traditional orchid in tropical and subtropical Asian regions, which has attracted attention for its fragrant flowers with diverse colors. This study aimed to investigate the effects of different extraction methods on the phenolic profile, total flavonoid and cyanidin-3-O-glucoside contents, and anti-aging properties of Rlc. Haw Yuan Beauty crude extracts. The crude extracts were obtained using solvent, ultrasonic, and supercritical carbon dioxide fluid extraction methods. The major phenolic compounds including gallic, chlorogenic, and caffeic acids were present in all the extracts. The extract obtained with solvent extraction showed the highest total flavonoid content, whereas that obtained with supercritical fluid extraction yielded the highest cyanidin-3-O-glucoside content. Additionally, the different extraction methods had a significant influence on the antioxidant, anti-elastase, and anti-collagenase activities (p < 0.05) of Rlc. Haw Yuan Beauty extracts. The crude extracts derived from the ultrasonic and supercritical carbon dioxide fluid extraction methods were not cytotoxic to human skin fibroblasts at any of the tested concentrations (31Ð500 µg/ml). Thus, the crude extracts from Rlc. Haw Yuan Beauty could be a safe and active ingredient in the production of skincare products in the cosmetic industry for human use. © 2021 Science Society of Thailand under Royal Patronage. All rights reserved.
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    Phytochemical screening, quantitative analysis of cyanidin-3-O-glucoside content, and anticancer activity of novel rice bran (Tubtim Chumphae rice)
    (Wolters Kluwer Medknow Publications, 2022) Rittipun Rungruang; Napassorn Peasura; Nattapon Kaisangsri; R. Rungruang; Department of Cosmetic Science, Faculty of Science and Technology, Suan Dusit University, Bangkok, 295 Nakhon Ratchasima Road, Dusit District, 10300, Thailand; email: rittipun_run@dusit.ac.th
    The objective of this research was to explore the phytochemicals in Tubtim Chumphae rice bran and determine their potential antioxidant and anticancer activities. The rice bran extract contained total phenolics, flavonoids, and anthocyanins as the major compounds. In addition, it exhibited the highest DPPH¥, followed by ABTS¥+, and FRAP radical scavenging activity. Moreover, the cytotoxic effect of the extract on Hep G2, SW620, KATO-III, BT474, and ChaGo-K-1 cancer cell lines was investigated; the obtained IC50 values were 144.6 ± 0.39, 116.9 ± 0.68, 99.6 ± 0.10, 94.4 ± 0.33, and 25.6 ± 0.45 _g/mL, respectively. Overall, the abovementioned results suggest that rice bran extract has potent anticancer activity owing to the induction of cell death in cancer cell lines. © 2022 Journal of Advanced Pharmaceutical Technology & Research.