T. KuljanabhagavadN. SriubolmasN. Ruangrungsi2025-03-102025-03-102011Pharmaceutical Chemistry Journal1573903110.1007/s11094-011-0587-x2-s2.0-80052825479https://repository.dusit.ac.th//handle/123456789/5020Heracleum siamicum Craib (Apiaceae), is an important herbal species having wide application in food flavoring processes. The flat-oval shaped fruit of H. siamicum Craib from North Thailand was hydrodistilled, and the chemical composition of the essential oil was analyzed by GC and GC-MS. The essential oil yield based on dried plant material was 1.25%, and twenty-five compounds (corresponding to 97.69% of the total weight) were identified. The main components were: n-octyl acetate (65.30%), o-cymene (10.35%), limonene (7.52%), _-2-carene (6.87%), cis-thujone (1.92%), isobornyl acetate (0.94%), n-octanol (0.73%), 1,8-cineol (0.62%), n-tridecanol (0.44%), and safrole (0.37%). H. siamicum essential oil demonstrated bactericidal and fungicidal activity against five bacterial strains and two fungal strains, as evaluated using agar diffusion in terms of the minimum inhibitory concentration. © 2011 Springer Science+Business Media, Inc.antimicrobial activitychemical compositionGC-MSHeracleum siamicumhydrodistillationvolatile oil analysisArticleScopus